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Ph.D. Maciej Przybyłek, prof. UMK

EDUCATION
A graduate of the Faculty of Technology and Chemical Engineering at the University of Technology and Life Science in Bydgoszcz (2010), field of study: Chemical Technology, field of specialization: Technology of Chemical Process.

PAPERS

2024

  • Cysewski P., Jeliński T., Przybyłek M., Mai A., Kułak J.: Experimental and machine-learning-assisted design of pharmaceutically acceptable deep eutectic solvents for the solubility improvement of non-selective COX inhibitors ibuprofen and ketoprofen, Molecules, s.n., vol. 29, nr 10, 2024, Numer artykułu: 2296, s. 1-19, DOI:10.3390/molecules29102296
  • Cysewski P., Jeliński T., Przybyłek M.: Experimental and theoretical insights into the intermolecular interactions in saturated systems of dapsone in conventional and deep eutectic solvents, Molecules, s.n., vol. 29, nr 8, 2024, Numer artykułu: 1743, s. 1-20, DOI:10.3390/molecules29081743
  • Cysewski P., Przybyłek M., Jeliński T.: Predicting sulfanilamide solubility in the binary mixtures using a reference solvent approach, Polimery w Medycynie, vol. 54, nr 1, 2024, s. 27-34, DOI:10.17219/pim/178284
  • Jeliński T., Przybyłek M., Mianowana M., Misiak K., Cysewski P.: Deep eutectic solvents as agents for improving the solubility of edaravone: experimental and theoretical considerations, Molecules, s.n., vol. 29, nr 6, 2024, Numer artykułu: 1261, s. 1-15, DOI:10.3390/molecules29061261
  • Jeliński T., Przybyłek M., Różalski R., Cysewski P.: Solubility of dapsone in deep eutectic solvents : experimental analysis, molecular insights and machine learning predictions, Polimery w Medycynie, vol. 54, nr 1, 2024, s. 15-25, DOI:10.17219/pim/177235
  • Jeliński T., Przybyłek M., Różalski R., Romanek K., Wielewski D., Cysewski P.: Tuning ferulic acid solubility in choline-chloride- and betaine-based deep eutectic solvents : experimental determination and machine learning modeling, Molecules, s.n., vol. 29, nr 16, 2024, Numer artykułu: 3841, s. 1-21, DOI:10.3390/molecules29163841
  • Przybyłek M., Tuwalska A., Ledziński D., Śmigiel S., Sionkowska A., Białas I., Bełdowski P.: Effect of nanohydroxyapatite on silk fibroin–chitosan interactions—molecular dynamics study, Applied Sciences-Basel, MDPI, vol. 14, nr 10, 2024, Numer artykułu: 4131, s. 1-15, DOI:10.3390/app14104131

2023

  • Cysewski Piotr, Jeliński Tomasz, Przybyłek Maciej: Intermolecular interactions of edaravone in aqueous solutions of ethaline and glyceline inferred from experiments and quantum chemistry computations, Molecules, 2023, vol. 28, nr 2, s.1-24, Numer artykułu:629. DOI:10.3390/molecules28020629
  • Przybyłek Maciej, Cysewski Piotr, Sionkowska Alina [i in.]: Collagen type II - chitosan interactions as dependent on hydroxylation and acetylation inferred from molecular dynamics simulations, Molecules, 2023, vol. 28, nr 1, s.1-16, Numer artykułu:154. DOI:10.3390/molecules28010154
  • Studziński W., Przybyłek Maciej, Gackowska A.: Application of gas chromatographic data and 2D molecular descriptors for accurate global mobility potential prediction, Environmental Pollution, 2023, vol. 317, s.1-13, Numer artykułu:120816. DOI:10.1016/j.envpol.2022.120816
  • Studziński Waldemar, Przybyłek Maciej: Treatment innovation using solar/UV, W: The treatment of pharmaceutical wastewater: innovative technologies and the adaptation of treatment systems / Khan Afzal Husain [i in.] (red.), 2023, Amsterdam, Oxford, Cambridge, Elsevier, s.179-216, ISBN 978-0-323-99160-5. DOI:10.1016/B978-0-323-99160-5.00005-9

2022

  • Bełdowski, P., Przybyłek, M., Sionkowska, A., Cysewski, P., Gadomska, M., Musiał, K., & Gadomski, A. (2022). Effect of chitosan deacetylation on its affinity to type III collagen : a molecular dynamics study. Materials, 15, 1–15. https://doi.org/10.3390/ma15020463
  • Cysewski, P., Jeliński, T., & Przybyłek, M. (2022). Application of COSMO-RS-DARE as a Tool for Testing Consistency of Solubility Data: Case of Coumarin in Neat Alcohols. Molecules, 27, 1–16. https://doi.org/10.3390/molecules27165274
  • Cysewski, P., Jeliński, T., & Przybyłek, M. (2022). New insights into thermodynamics of solutes in neat and complex solvents. Molecules, 27, 1–4. https://doi.org/10.3390/molecules27186131
  • Przybyłek, M., Miernicka, A., Nowak, M., & Cysewski, P. (2022). New screening protocol for effective green solvents selection of benzamide, salicylamide and ethenzamide. Molecules, 27, 1–22. https://doi.org/10.3390/molecules27103323
  • Bełdowski, P., Przybyłek, M., Kruszewska, N., Sionkowska, A., & Cysewski, P. (2022). The structural and energetical consequences of praline hydroxylation on collagen-chitosan/hyaluronan affinity. In F. Guittard (Ed.), International Rendez-Vous for mobility, innovation, biomimicry connection (p. 20). Universite Cote d’Azur Nice.
  • Bełdowski, P., Przybyłek, M., Sionkowska, A., & Cysewski, P. (2022). The structural and energetical consequences of chitosan deacetylation degree on its affinity to collagen [Abstract].
  • Cysewski, P.; Jelinski, T.;Przybyłek, M.; Nowak, W.; Olczak,M. Solubility Characteristics of Acetaminophen and Phenacetin in Binary Mixtures of Aqueous Organic Solvents: Experimental and Deep Machine Learning Screening of Green Dissolution Media. Pharmaceutics 2022, 14, 2828. https://doi.org/10.3390/pharmaceutics14122828
  • Cysewski, P.; Jeliński, T.; Przybyłek, M. Intermolecular Interactions of Edaravone in Aqueous Solutions of Ethaline and Glyceline Inferred from Experiments and Quantum Chemistry Computations. Molecules 2023, 28, 629. https://doi.org/10.3390/molecules28020629

2021

  • Cysewski Piotr, Walczak P., Ziółkowska D., Grela I., Przybyłek Maciej. Experimental and theoretical studies on the Sulfamethazine-Urea and Sulfamethizole-Urea solid-liquid equilibria. J. Drug Deliv. Sci. Technol.: 2021 : Vol. 61, s. 1-11, 102186. https://doi.org/10.1016/j.jddst.2020.102186
  • Cysewski Piotr, Jeliński Tomasz, Cymerman P., Przybyłek Maciej. Solvent screening for solubility enhancement of theophylline in neat, binary and ternary nades solvents : new measurements and ensemble machine learning. Int. J. Mol. Sci.: 2021 : Vol. 22, nr 14, s. 1-21, 7347. https://doi.org/10.3390/ijms22147347
  • Przybyłek Maciej, Walczak P., Ziółkowska D., Grela I., Cysewski Piotr. Studies on the solid-liquid equilibria and intermolecular interactions Urea binary mixtures with Sulfanilamide and Sulfacetamide. J. Chem. Thermodyn.: 2021 : Vol. 153, s. 1-13, 106308. https://doi.org/10.1016/j.jct.2020.106308
  • Przybyłek Maciej, Kowalska A., Tymorek N., Dziaman T., Cysewski Piotr. Thermodynamic characteristics of phenacetin in solid state and saturated solutions in several neat and binary solvents. Molecules: 2021 : Vol. 26, nr 13, s. 1-19, 4078. https://doi.org/10.3390/molecules26134078
  • Cysewski Piotr, Przybyłek Maciej, Kowalska A., Tymorek N. Thermodynamics and intermolecular interactions of nicotinamide in neat and binary solutions : experimental measurements and COSMO-RS concentration dependent reactions investigations. Int. J. Mol. Sci.: 2021 : Vol. 22, nr 14, s. 1-21, 7365. https://doi.org/10.3390/ijms22147365

2020

  • Tomasz Jeliński, Natalia Bugalska, Kinga Koszucka, Maciej Przybyłek, Piotr Cysewski - Solubility of sulfanilamide in binary solvents containing water: Measurements and prediction using Buchowski-Ksiazczak solubility model, Journal of Molecular Liquids Volume 319, 1 December 2020, 114342 doi:10.1016/j.molliq.2020.114342

2019

  • Maciej Przybyłek, Tomasz Jeliński, Piotr Cysewski.  Application of multivariate adaptive regression splines (MARSplines) for predicting Hansen solubility parameters based on 1D and 2D molecular descriptors computed from SMILES string. J. Chem.  2019 : Vol. 2019, s. 1-15.
  • Maciej Przybyłek, Ł. Recki, K. Mroczyńska, Tomasz Jeliński, Piotr Cysewski. Experimental and theoretical solubility advantage screening of bi-component solid curcumin formulations. J. Drug Deliv. Sci. Technol. 2019 : Vol. 50, s. 125-135.
  • Tomasz Jeliński, Maciej Przybyłek, Piotr Cysewski. Natural deep eutectic solvents as agents for improving solubility, stability and delivery of curcumin. Pharm. Res.-DORDR 2019 : Vol. 36, 116, s. 1-10.
  • Piotr Cysewski, Maciej Przybyłek. Predicting value of binding constants of organic ligands to beta-cyclodextrin: application of MARSplines and descriptors encoded in SMILES string. Symmetry-Basel 2019 : Vol. 11, nr 7, s. 922; 1-11.
  • Tomasz Jeliński, Maciej Przybyłek, Piotr Cysewski. Solubility advantage of sulfanilamide and sulfacetamide in natural deep eutectic systems : experimental and theoretical investigations. Drug Dev. Ind. Pharm. 2019 : Vol. 45, nr 7, s. 1120-1129.

2018

  • Maciej Przybyłek, Piotr Cysewski.Distinguishing cocrystals from simple eutectic mixtures : phenolic acids as potential pharmaceutical coformers.Cryst. Growth Des.2018 : Vol. 18, nr 6, s. 3524-3534.

2017

  • M. Przybyłek, D. Ziółkowska, K. Mroczyńska, P. Cysewski, Applicability of phenolic acids as effective enhancers of cocrystal solubility of methylxanthines. Cryst. Growth Des. 2017
  • W. Studziński, A. Gackowska, M. Przybyłek, J. Gaca, Studies on the formation of formaldehyde during 2-ethylhexyl 4-(dimethylamino)benzoate demethylation in the presence of reactive oxygen and chlorine species.
  • Piotr Cysewski, Maciej Przybyłek. Selection of effective cocrystals former for dissolution rate improvement of active pharmaceutical ingredients based on lipoaffinity index. Eur. J. Pharm. Sci. 2017 : Vol. 107, s. 87-96.

2016

  • M. Przybyłek, D. Ziółkowska, K. Mroczyńska, P. Cysewski, Propensity of salicylamide and ethenzamide cocrystallization with aromatic carboxylic acids.Eur. J. Pharm. Sci. 2016, 85, 132-140
  • Maciej Przybyłek, Dorota Ziółkowska, Karina Mroczyńska, Piotr Cysewski, Propensity of salicylamide and ethenzamide cocrystallization with aromatic carboxylic acids. European Journal of Pharmaceutical Sciences, 85, 132–140 (2016). doi: 10.1016/j.ejps.2016.02.010
  • Piotr Cysewski, Maciej Przybyłek, Dorota Ziółkowska, Karina Mroczyńska, Exploring the cocrystallization potential of urea and benzamide. Journal of Molecular Modeling, 22(5), 1-10 (2016), doi: 10.1007/s00894-016-2964-6
  • Maciej Przybyłek, Dorota Ziółkowska, Mirosław Kobierski, Karina Mroczyńska, Piotr Cysewski, Utilization of oriented crystal growth for screening of aromatic carboxylic acids cocrystallization with urea. Journal of Crystal Growth 433, 128–138 (2016), doi: 10.1016/j.jcrysgro.2015.10.015
  • Alicja Gackowska, Maciej Przybyłek, Waldemar Studziński, Jerzy Gaca, Formation of chlorinated breakdown products during degradation of sunscreen agent, 2-ethylhexyl-4-methoxycinnamate in the presence of sodium hypochlorite. Environmental Science and Pollution Research 23 (2), 1886–1897 (2016), doi: 10.1007/s11356-015-5444-0

2015

  • Maciej Przybyłek, Piotr Cysewski, Maciej Pawelec, Dorota Ziółkowska, Mirosław Kobierski, On the origin of surface imposed anisotropic growth of salicylic and acetylsalicylic acids crystals during droplet evaporation. Journal of Molecular Modeling 21 (3), 1–12 (2015), doi: 10.1007/s00894-015-2599-z
  • Piotr Cysewski, Maciej Przybyłek, Tomasz Miernik, Mirosław Kobierski, Dorota Ziółkowska, On the origin of surfaces-dependent growth of benzoic acid crystal inferred through the droplet evaporation method. Structural Chemistry 26 (3), 705–712 (2015), doi: 10.1007/s11224-014-0528-x

2014

  • Alicja Gackowska, Maciej Przybyłek, Waldemar Studziński, Jerzy Gaca, Experimental and theoretical studies on the photodegradation of 2-ethylhexyl 4-methoxycinnamate in the presence of reactive oxygen and chlorine species. Central European Journal of Chemistry 12 (5), 612–623 (2014), doi: 10.2478/s11532-014-0522-6

2013

  • Maciej Przybyłek, Studies on the charge density distribution in p-substituted phenylnitrenium cation. Ekologia i Technika, 21(5), 230–236 (2013).

2012

  • Piotr Cysewski, Tomasz Jeliński, Maciej Przybyłek, Aleksander Shyichuk, Color prediction from first principle quantum chemistry computations: a case of alizarin dissolved in methanol. New Journal of Chemistry 36, 1836–1843 (2012), doi: 10.1039/c2nj40327g
  • Maciej Przybyłek, Jerzy Gaca, Reaction of aniline with ammonium persulphate and concentrated hydrochloric acid: Experimental and DFT studies. Chemical Papers 66 (7), 699–708 (2012), doi: 10.2478/s11696-012-0163-1

2011

  • Maciej Przybyłek, Jerzy Gaca, Oksychlorowanie związków organicznych, Chemik 65 (4), 297–300 (2011).