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Ph.D. Przemysław Czeleń

EDUCATION
06.2004 M.Sc. in Chemical Technology, University of Technology and Life Sciences in Bydgoszcz, 
06.2011 PhD degree in chemical sciences University of Technology and Life Sciences in Bydgoszcz, PhD thesis: " Description of molecular basis of telomeric DNA oxidation, with use of computational chemistry methods"

PAPERS

2024

  • Szupryczyński K., Czeleń P., Jeliński T., Szefler B.: What is the reason that the pharmacological future of chemotherapeutics in the treatment of lung cancer could be most closely related to nanostructures? Platinum drugs in therapy of non-small and small cell lung cancer and their unexpected, possible interactions : the review, International journal of nanomedicine, vol. 19, 2024, s. 9503-9547, DOI:10.2147/IJN.S469217

2023

  • Szefler Beata, Makarewicz Adrianna, Obońska Ewa, Rutkowska Dorota, Czeleń Przemysław: Docking of carboplatin towards chosen nanostructures, Biointerface Research in Applied Chemistry, vol. 13, nr 2, 2023, s. 1-10, DOI:10.33263/BRIAC132.109
  • Czeleń Przemysław, Szefler Beata, Skotnicka Agnieszka: A computational study of the immobilization of new 5-nitroisatine derivatives with the use of C60-based functionalized nanocarriers, Symmetry-Basel, 2023, vol. 15, nr 1, s.1-16, Numer artykułu:226. DOI:10.3390/sym15010226
  • Kabatc-Borcz Janina, Czeleń Przemysław, Skotnicka Agnieszka: Synthesis and Spectroscopic Properties of Selected Acrylic and Methacrylic Derivatives of 2-Mercaptobenzothiazole, Symmetry-Basel, 2023, vol. 15, nr 2, s.1-12, Numer artykułu:370. DOI:10.3390/sym15020370
  • Szefler Beata, Czeleń Przemysław: Will the interactions of some platinum (II)-based drugs with B-vitamins reduce their therapeutic effect in cancer patients? Comparison of chemotherapeutic agents such as cisplatin, carboplatin and oxaliplatin: a review, International Journal of Molecular Sciences, 2023, vol. 24, nr 2, s.1-21, Numer artykułu:1548. DOI:10.3390/ijms24021548

2022

  • Czeleń, P., Skotnicka, A., & Szefler, B. (2022). Designing and Synthesis of New Isatin Derivatives as Potential CDK2 Inhibitors. International Journal of Molecular Sciences, 23, 1–18. https://doi.org/10.3390/ijms23148046
  • Szefler, B., Czeleń, P., Wojtkowiak, K., & Jezierska, A. (2022). Affinities to oxaliplatin: vitamins from B group vs. nucleobases. International Journal of Molecular Sciences, 23, 1–15. https://doi.org/10.3390/ijms231810567
  • Szefler, B., Czeleń, P., Kruszewski, S., Siomek-Górecka, A., & Krawczyk, P. (2022). The assessment of physicochemical properties of Cisplatin complexes with purines and vitamins B group. Journal of Molecular Graphics & Modelling, 113, 1–15. https://doi.org/10.1016/j.jmgm.2022.108144
  • Czeleń, P., & Szefler, B. (2022). The development of new isatin derivatives as promising competitive inhibitors of CDK-2 and GSK-3&#946. In W. U. Medyczny (Ed.), Interdisciplinary Conference on Drug Sciences, ACCORD 2022 „Synergy of interdisciplinary innovations“. Abstract book (p. 208).
  • Szefler, B., & Czeleń, P. (2022). Why the diet is so important during chemotherapy for lung cancer? Molecular modeling (and not only) of affinity of some Pt derivatives to B vitamins. In W. U. Medyczny (Ed.), Interdisciplinary Conference on Drug Sciences, ACCORD 2022 „Synergy of interdisciplinary innovations“. Abstract book (p. 194).

2021

  • Skotnicka A., Czeleń Przemysław. Substituent and solvent polarity on the spectroscopic properties in azo derivatives of 2-hydroxynaphthalene and their difluoroboranes complexes. Materials: 2021 : Vol. 14, nr 12, s. 1-19, 3387. https://doi.org/10.3390/ma14123387
  • Szefler Beata, Czeleń Przemysław, Krawczyk Przemysław. The affinity of carboplatin to B-vitamins and nucleobases. Int. J. Mol. Sci.: 2021 : Vol. 22, nr 4, s. 1-11, 3634. https://doi.org/10.3390/ijms22073634
  • Czeleń Przemysław, Szefler Beata. The oxindole derivatives, new promising GSK-3b~oo inhibitors as one of the potential treatments for Alzheimer's disease : a molecular dynamics approach. Biology: 2021 : Vol. 10, nr 4, s. 1-17, 332 https://doi.org/10.3390/biology10040332

2019

  • T. Janek, Przemysław Czeleń, E. J. Gudina, L. R. Rodrigues, Ż. Czyżnikowska. Biomolecular interactions of lysosomotropic surfactants with cytochrome c and its effect on the protein conformation: A biophysical approach. Int. J. Biol. Macromol. 2019 : Vol. 126, s. 1177-1185.
  • A. Skotnicka, Przemysław Czeleń, R. Gawinecki. Tautomeric equilibria in solutions of 2-phenacylbenzimidazoles. Heteroatom Chem. 2019 : Vol. 2019, s. 1-9.
  • Beata Szefler, Przemysław Czeleń, Docking of cisplatin on fullerene derivatives and some cube rhombellane functionalized homeomorphs, Symmetry-Basel, 2019, Vol. 11, nr 7, s. 874, 1-11, DOI: 10.3390/sym11070874
  • Beata Szefler, Przemysław Czeleń, Docking of polyethylenimines derivatives on cube rhombellane functionalized homeomorphs, Symmetry-Basel, 2019, Vol. 11, nr 8, s. 1048, 1-14, DOI: 10.3390/sym11081048
  • Przemysław Czeleń, Beata Szefler, The immobilization of oxindole derivatives with use of cube rhombellane homeomorphs, Symmetry-Basel, 2019, Vol. 11, nr 7, s. 900, 1-11, DOI: 10.3390/sym11070900
  • Przemysław Czeleń, Beata Szefler,  The immobilization of ChEMBL474807 molecules using different classes of nanostructures, Symmetry-Basel, 2019, Vol. 11, nr 8, s. 980, 1-13, DOI: 10.3390/sym11080980
  • Beata Szefler, Przemysław Czeleń, Adam Szczepanik, Piotr Cysewski, Does Affinity of Cisplatin to B-Vitamins Impair the Therapeutic Effect in the Case of Patient with Lung Cancer Consuming Carrot or Beet Juice?, Anti-Cancer Agents in Medicinal Chemistry, 2019, 19, 000-000, DOI: 10.2174/1871520619666190325150624

2018

  • Beata Szefler, Przemysław Czeleń, M. V. Diudea.Docking of indolizine derivatives on cube rhombellane functionalized homeomorphs.Stud. Univ. Babes-Bolyai Chem.2018 : Vol. 63, nr 2, s. 7-18.
  • Przemysław Krawczyk, Przemysław Czeleń, Piotr Cysewski.Reactive group effects on the photophysical and biological properties of 2-phenyl-1H-phenanthro[9,10-d]imidazole derivatives as fluorescent markers.Org. Biomol. Chem.2018 : Vol. 16, nr 20, s. 3788-3800.

2017

  • B. Szefler, P. Czeleń, M.V. Diudea, Understanding the action of indolizines as biologically active moieties : a molecular dynamics study. Curr. Comput.-Aided Drug Des. 2017, 13(1), 22-29
  • Przemysław Czeleń, Beata Szefler, Przemysław Krawczyk. Docking and molecular dynamics study of CDK2 inhibition by new indoline derivatives. Modeling Interactions in Biomolecules VIII. J. Burda. Praha : MATFYZPRESS, Publishing House of the Faculty of Mathematics and Physics Charles University in Prague, 2017 : Plzeń, 2017.09.03
  • Przemysław Czeleń. Inhibition mechanism of CDK-2 and GSK-3β by a sulfamoylphenyl derivative of indoline - a molecular dynamics study. J. Mol. Model. 2017 : Vol. 23, nr 8, s. 230, 1-11.
  • Beata Szefler, Przemysław Czeleń. Potential inhibitory effect of indolizine derivatives on the two enzymes : nicotinamide phosphoribosyltransferase and beta lactamase, a molecular dynamics study. J. Mol. Model. 2017 : Vol. 23, nr 7, s. 208, 1-9.
  • A. Skotnicka, Przemysław Czeleń, R. Gawinecki. Tautomeric equilibria in solutions of 1-methyl-2-phenacylbenzimidazoles. J. Mol. Struc. 2017 : Vol. 1134, s. 546-551.
  • Przemysław Krawczyk, Przemysław Czeleń, Beata Szefler, Tomasz Jeliński, Piotr Cysewski. The reactive group effects on the photophysical and biological properties of the fluorescent probe based on chalcone derivatives. Modeling Interactions in Biomolecules VIII. J. Burda. Praha : MATFYZPRESS, Publishing House of the Faculty of Mathematics and Physics Charles University in Prague, 2017 s. 74. : Plzeń, 2017.09.03
  • Beata Szefler, Przemysław Czeleń, Przemysław Krawczyk, Piotr Cysewski. Theoretical study on cisplatin binding to B-vitamins : could the therapeutic effect of cisplatin be decreased if a patient with lung cancer drinks carrot or beet juice? Modeling Interactions in Biomolecules VIII. J. Burda. Praha : MATFYZPRESS, Publishing House of the Faculty of Mathematics and Physics Charles University in Prague, 2017 : Plzeń, 2017.09.03

2016

  • P. Czeleń, Molecular dynamics study on inhibition mechanism of CDK-2 and GSK-3β by CHEMBL272026 molecule. Struct. Chem. 2016, 27, 1807-1818
  • Physical nature of intermolecular interactions inside Sir2 homolog active site: molecular dynamics and ab initio study P. Czeleń, Ż. Czyżnikowska, J Mol Model (2016) 22:120, doi: 10.1007/s00894-016-2992-2

2015

  • Molecular dynamics study of the inhibitory effects of ChEMBL474807 on the enzymes GSK-3β and CDK-2 P. Czeleń, B. Szefler J MolModel (2015) 21:74, doi: 10.1007/s00894-015-2627-z

2013

  • Structural and energetic properties of canonical and oxidizedtelomeric complexes studied by molecular dynamics simulations P. Czeleń, P. Cysewski, J Mol Model (2013) 19: 3339-3349, doi: 10.1007/s00894-013-1859-z
  • Tautomeric equilibria in solutions of 2-phenacylbenzoxazoles, A. Skotnicka, E. Kolehmainen, P. Czeleń, R. Gawinecki, Int. J. Mol. Sci. (2013), 14, 4444-4460; doi: 10.3390/ijms14034444

2012

  • Quantum chemical study of hole transfer coupling in nucleic acid base complexes containing 7-deazaadenine, M. Mikołajczyk , Ż Czyżnikowska , P. Czeleń , U. Bielecka, R. Zaleśny, P. Toman , W. Bartkowiak, Chem. Phys. Lett. (2012) 537:94–100 doi: 10.1016/j.cplett.2012.04.018

2010

  • Structural and energetic consequences of oxidation of d(ApGpGpGpTpT) telomere repeat unit in complex with TRF1 protein, P. Cysewski, P. Czeleń , J Mol Model (2010) 16:1797–1807, doi: 10.1007/s00894-010-0730-8

2009

  • Structural and energetic heterogeneities of canonical and oxidized central guanine triad of B-DNA telomeric fragments, P. Cysewski, P. Czeleń , J. Mol. Mod., (2009) 15:607-613, doi: 10.1007/s00894-008-0438-1

2008

  • The post-SCF quantum chemistry characteristics of the guanine–guanine stacking B-DNA, P. Cysewski, Ż. Czyżnikowska, R. Zaleśny, P. Czeleń, Phys. Chem. Chem. Phys., (2008) 10:2665–2672 , doi: 10.1039/b718635e

2007

  • Theoretical analysis of the effects of guanine oxidative damage on the properties of B-DNA telomere fragments, P. Cysewski, P. Czeleń , J. Mol. Mod., (2007) 13:739–75, doi: 10.1007/s00894-007-0186-7

SCIENTIFIC CONFERENCES

  • Molecular Dynamic Simulation of the Effects of Oxidative Damage on the Structure of Telomeric DNA ;Modeling & Design of Molecular Materials, 2006 Wrocław,
  • The post-SCF quantum chemistry study on the structural and energetic properties of stacked pairs found in central triad of telomeric B-DNA fragment; Modeling & Design of Molecular Materials, 2008 Piechowice,
  • The post-SCF quantum chemistry study on the structural and energetic heterogeneities of canonical and oxidized basepairs found in telomeric complexes; Modeling Interaction in Biomolecules IV, 2009 Hruba Skala, Czech Republic,
  • Molecular dynamics study of ChEMBL474807 inhibition properties against GSK3 and CDK2 enzymes; Modeling and Design of Molecular Materials 2014 Kudowa-Zdrój, 2014
  • Physical nature of intermolecular interactions within Sir2 homolog active site: Molecular dynamics and SAPT-DFT study; Modeling and Design of Molecular Materials 2014 Kudowa-Zdrój, 2014

TEACHING EXPERIENCE
Physical Chemistry and Instrumental Analysis for Pharmacy, Laboratory Medicine and Biotechnology

RESEARCH INTERESYS
Analysis of the impact of oxidative changes on the properties of nucleic acids. Interactions between nucleic acids and proteins. Analysis of interactions between the compounds with pharmacological properties with  active sites of enzymes realized with use docking and molecular dynamics simulation.