Ph.D. Przemysław Czeleń

EDUCATION
06.2004 M.Sc. in Chemical Technology, University of Technology and Life Sciences in Bydgoszcz, 
06.2011 PhD degree in chemical sciences University of Technology and Life Sciences in Bydgoszcz, PhD thesis: " Description of molecular basis of telomeric DNA oxidation, with use of computational chemistry methods"

PAPERS

 

2019

  • T. Janek, Przemysław Czeleń, E. J. Gudina, L. R. Rodrigues, Ż. Czyżnikowska. Biomolecular interactions of lysosomotropic surfactants with cytochrome c and its effect on the protein conformation: A biophysical approach. Int. J. Biol. Macromol. 2019 : Vol. 126, s. 1177-1185.
  • A. Skotnicka, Przemysław Czeleń, R. Gawinecki. Tautomeric equilibria in solutions of 2-phenacylbenzimidazoles. Heteroatom Chem. 2019 : Vol. 2019, s. 1-9.
  • Beata Szefler, Przemysław Czeleń, Docking of cisplatin on fullerene derivatives and some cube rhombellane functionalized homeomorphs, Symmetry-Basel, 2019, Vol. 11, nr 7, s. 874, 1-11, DOI: 10.3390/sym11070874
  • Beata Szefler, Przemysław Czeleń, Docking of polyethylenimines derivatives on cube rhombellane functionalized homeomorphs, Symmetry-Basel, 2019, Vol. 11, nr 8, s. 1048, 1-14, DOI: 10.3390/sym11081048
  • Przemysław Czeleń, Beata Szefler, The immobilization of oxindole derivatives with use of cube rhombellane homeomorphs, Symmetry-Basel, 2019, Vol. 11, nr 7, s. 900, 1-11, DOI: 10.3390/sym11070900
  • Przemysław Czeleń, Beata Szefler,  The immobilization of ChEMBL474807 molecules using different classes of nanostructures, Symmetry-Basel, 2019, Vol. 11, nr 8, s. 980, 1-13, DOI: 10.3390/sym11080980
  • Beata Szefler, Przemysław Czeleń, Adam Szczepanik, Piotr Cysewski, Does Affinity of Cisplatin to B-Vitamins Impair the Therapeutic Effect in the Case of Patient with Lung Cancer Consuming Carrot or Beet Juice?, Anti-Cancer Agents in Medicinal Chemistry, 2019, 19, 000-000, DOI: 10.2174/1871520619666190325150624

2018

  • Beata Szefler, Przemysław Czeleń, M. V. Diudea.Docking of indolizine derivatives on cube rhombellane functionalized homeomorphs.Stud. Univ. Babes-Bolyai Chem.2018 : Vol. 63, nr 2, s. 7-18.
  • Przemysław Krawczyk, Przemysław Czeleń, Piotr Cysewski.Reactive group effects on the photophysical and biological properties of 2-phenyl-1H-phenanthro[9,10-d]imidazole derivatives as fluorescent markers.Org. Biomol. Chem.2018 : Vol. 16, nr 20, s. 3788-3800.

2017

  • B. Szefler, P. Czeleń, M.V. Diudea, Understanding the action of indolizines as biologically active moieties : a molecular dynamics study. Curr. Comput.-Aided Drug Des. 2017, 13(1), 22-29
  • Przemysław Czeleń, Beata Szefler, Przemysław Krawczyk. Docking and molecular dynamics study of CDK2 inhibition by new indoline derivatives. Modeling Interactions in Biomolecules VIII. J. Burda. Praha : MATFYZPRESS, Publishing House of the Faculty of Mathematics and Physics Charles University in Prague, 2017 : Plzeń, 2017.09.03
  • Przemysław Czeleń. Inhibition mechanism of CDK-2 and GSK-3β by a sulfamoylphenyl derivative of indoline - a molecular dynamics study. J. Mol. Model. 2017 : Vol. 23, nr 8, s. 230, 1-11.
  • Beata Szefler, Przemysław Czeleń. Potential inhibitory effect of indolizine derivatives on the two enzymes : nicotinamide phosphoribosyltransferase and beta lactamase, a molecular dynamics study. J. Mol. Model. 2017 : Vol. 23, nr 7, s. 208, 1-9.
  • A. Skotnicka, Przemysław Czeleń, R. Gawinecki. Tautomeric equilibria in solutions of 1-methyl-2-phenacylbenzimidazoles. J. Mol. Struc. 2017 : Vol. 1134, s. 546-551.
  • Przemysław Krawczyk, Przemysław Czeleń, Beata Szefler, Tomasz Jeliński, Piotr Cysewski. The reactive group effects on the photophysical and biological properties of the fluorescent probe based on chalcone derivatives. Modeling Interactions in Biomolecules VIII. J. Burda. Praha : MATFYZPRESS, Publishing House of the Faculty of Mathematics and Physics Charles University in Prague, 2017 s. 74. : Plzeń, 2017.09.03
  • Beata Szefler, Przemysław Czeleń, Przemysław Krawczyk, Piotr Cysewski. Theoretical study on cisplatin binding to B-vitamins : could the therapeutic effect of cisplatin be decreased if a patient with lung cancer drinks carrot or beet juice? Modeling Interactions in Biomolecules VIII. J. Burda. Praha : MATFYZPRESS, Publishing House of the Faculty of Mathematics and Physics Charles University in Prague, 2017 : Plzeń, 2017.09.03

2016

  • P. Czeleń, Molecular dynamics study on inhibition mechanism of CDK-2 and GSK-3β by CHEMBL272026 molecule. Struct. Chem. 2016, 27, 1807-1818
  • Physical nature of intermolecular interactions inside Sir2 homolog active site: molecular dynamics and ab initio study P. Czeleń, Ż. Czyżnikowska, J Mol Model (2016) 22:120, doi: 10.1007/s00894-016-2992-2

2015

  • Molecular dynamics study of the inhibitory effects of ChEMBL474807 on the enzymes GSK-3β and CDK-2 P. Czeleń, B. Szefler J MolModel (2015) 21:74, doi: 10.1007/s00894-015-2627-z

2013

  • Structural and energetic properties of canonical and oxidizedtelomeric complexes studied by molecular dynamics simulations P. Czeleń, P. Cysewski, J Mol Model (2013) 19: 3339-3349, doi: 10.1007/s00894-013-1859-z
  • Tautomeric equilibria in solutions of 2-phenacylbenzoxazoles, A. Skotnicka, E. Kolehmainen, P. Czeleń, R. Gawinecki, Int. J. Mol. Sci. (2013), 14, 4444-4460; doi: 10.3390/ijms14034444

2012

  • Quantum chemical study of hole transfer coupling in nucleic acid base complexes containing 7-deazaadenine, M. Mikołajczyk , Ż Czyżnikowska , P. Czeleń , U. Bielecka, R. Zaleśny, P. Toman , W. Bartkowiak, Chem. Phys. Lett. (2012) 537:94–100 doi: 10.1016/j.cplett.2012.04.018

2010

  • Structural and energetic consequences of oxidation of d(ApGpGpGpTpT) telomere repeat unit in complex with TRF1 protein, P. Cysewski, P. Czeleń , J Mol Model (2010) 16:1797–1807, doi: 10.1007/s00894-010-0730-8

2009

  • Structural and energetic heterogeneities of canonical and oxidized central guanine triad of B-DNA telomeric fragments, P. Cysewski, P. Czeleń , J. Mol. Mod., (2009) 15:607-613, doi: 10.1007/s00894-008-0438-1

2008

  • The post-SCF quantum chemistry characteristics of the guanine–guanine stacking B-DNA, P. Cysewski, Ż. Czyżnikowska, R. Zaleśny, P. Czeleń, Phys. Chem. Chem. Phys., (2008) 10:2665–2672 , doi: 10.1039/b718635e

2007

  • Theoretical analysis of the effects of guanine oxidative damage on the properties of B-DNA telomere fragments, P. Cysewski, P. Czeleń , J. Mol. Mod., (2007) 13:739–75, doi: 10.1007/s00894-007-0186-7

SCIENTIFIC CONFERENCES

  • Molecular Dynamic Simulation of the Effects of Oxidative Damage on the Structure of Telomeric DNA ;Modeling & Design of Molecular Materials, 2006 Wrocław,
  • The post-SCF quantum chemistry study on the structural and energetic properties of stacked pairs found in central triad of telomeric B-DNA fragment; Modeling & Design of Molecular Materials, 2008 Piechowice,
  • The post-SCF quantum chemistry study on the structural and energetic heterogeneities of canonical and oxidized basepairs found in telomeric complexes; Modeling Interaction in Biomolecules IV, 2009 Hruba Skala, Czech Republic,
  • Molecular dynamics study of ChEMBL474807 inhibition properties against GSK3 and CDK2 enzymes; Modeling and Design of Molecular Materials 2014 Kudowa-Zdrój, 2014
  • Physical nature of intermolecular interactions within Sir2 homolog active site: Molecular dynamics and SAPT-DFT study; Modeling and Design of Molecular Materials 2014 Kudowa-Zdrój, 2014

TEACHING EXPERIENCE
Physical Chemistry and Instrumental Analysis for Pharmacy, Laboratory Medicine and Biotechnology

RESEARCH INTERESYS
Analysis of the impact of oxidative changes on the properties of nucleic acids. Interactions between nucleic acids and proteins. Analysis of interactions between the compounds with pharmacological properties with  active sites of enzymes realized with use docking and molecular dynamics simulation.